PhD thesis defense. Advances for Alzheimer’s disease diagnostics through the integration of spectroscopy and chemometrics

CIC nanoGUNE Seminars

Speaker: Eneko López Corrillero
CIC nanoGUNE
When: 2025/09/30
11:00
Place: Facultad de Educación, Filosofía y Antropología (HEFA), Edif. I, HEMICICLO
Host: Andreas Seifert & José Manuel Amigo
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PhD thesis defense. Advances for Alzheimer’s disease diagnostics through the integration of spectroscopy and chemometrics

This thesis investigates vibrational spectroscopy in combination with chemometrics as a liquid biopsy for Alzheimer’s disease (AD) diagnostics before symptoms. A cross-validated model from cerebrospinal fluid Raman spectra achieved >90% accuracy across 2 different cohorts, while a more tutorial-like study showed how improper validation could inflate model performance and proposed strategies against overfitting. Hyperspectral imaging further revealed AD-related signals concentrated in inner dried biofluid regions. Together, the work highlights Raman spectroscopy’s diagnostic potential, with rigorous validation and spatially informed measurement practices.