Ph-D Mid-term Seminars series: Raman Spectroscopy and Chemometrics: The Future of Lung Cancer Detection?

CIC nanoGUNE Seminars

Speaker

Harun Hano
Nanoengineering group, CIC nanoGUNE

When

2023/10/23
11:00

Place

nanoGUNE seminar room, Tolosa Hiribidea 76, Donostia - San Sebastian

Host

Beatriz Martin García

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Lung cancer is the leading cause of cancer-related deaths which emphasises the urgent need for efficient diagnostic methods. The potential of Raman spectroscopy, a non-invasive approach, will be presented by evaluating human blood plasma samples from lung cancer patients and healthy people. It starts by testing 16 machine learning models which were evaluated for their accuracy and receiver operating characteristic curves, employing four strategies: the combination of dimensionality reduction with classifiers; application of feature selection prior to classification; standalone classifiers; and a unified predictive model. Next, it focuses on enhancing the prediction power of the algorithms by selecting the most critical features and eliminating the redundant and irrelevant ones. Overall, each model delivers creditable figures of merit and demonstrate that Raman spectroscopy represents a powerful method for future in vitro diagnostics of lung cancer.