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**Engineering enzyme surfaces for the fabrication of heterogeneous catalysts
and chemoenzymatic nanoreactors**
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The development of polymeric hybrid materials in which enzymes are embedded is
an attractive approach to both immobilize and stabilize biocatalysts. Our
group has recently developed a versatile methodology to encapsulate enzymes
individually within a polymeric material, resulting in the so-called single
enzyme nanogels (SENs). This acrylic-based polymer does not show diffusional
issues and improves the stability of the enzyme significantly. Moreover, the
polymeric shell can be decorated with many functional groups, for example,
imidazolate residues, in order to coordinate metal cations or organic
molecules. The combination of confined imidazole motifs and transition
metallic cations triggers the precipitation of the engineered enzymes and the
fabrication of diverse micro-/nanostructures [1,2,3]. Lately, we have also
focused our attention on synthetizing advanced chemoenzymatic nanoreactors by
confining SENs and organic catalysts for bioremediation [4].
[1] A. Rodriguez-Abetxuko, M.C. Morant-Miñana, F. López-Gallego, L. Yate, A.
Seifert, M. Knez, A. Beloqui, Adv. Funct. Mater. **2018** , 28 (35), 1803115
[2] A. Rodriguez-Abetxuko, M.C. Morant-Miñana, M. Knez, A. Beloqui, ACS Omega
**2019** , 4 (3), 5172-5179
[3] A. Rodriguez-Abetxuko, D. Sánchez-deAlcázar, A. L. Cortajarena, A.
Beloqui, Adv. Mater. Interfaces. **2019** , 6, 19005
[4] A. Rodriguez-Abetxuko, P. Muñumer, M. Okuda, J. Calvo, M. Knez, A.
Beloqui, Adv. Funct. Mater. **2020**. Accepted
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