High throughput statistical approaches in label-free biosensing
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High throughput statistical approaches in label-free biosensing
CIC nanoGUNE Seminars
- Speaker
-
F. G. Bosco, TU Denmark
- When
-
2012/02/03
12:00
- Place
- nanoGUNE seminar room, Tolosa Hiribidea 76, Donostia - San Sebastian
- Add to calendar
-
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Sensors are crucial in many daily operations including security, environmental
control, human diagnostics and patient monitoring. Screening and on-line
monitoring require reliable and high-throughput sensing. The use of detection
systems based on multisensory approaches help to reduce false alarms and
provides new opportunities for real-time analysis of specific analytes. By
simultaneously applying a variety of sensor techniques to a sample it is
possible to detect the presence of specific molecules with a higher confidence
and give a more reliable and fast response, compared to single-analysis
sensing systems. We present the demonstration of high-throughput label-free
sensor platforms utilizing micromechanical sensors and Raman-based
spectroscopy. Multiple sensing techniques (chemo-responsive colorimetric
arrays, calorimetric devices and electrochemical sensors) are further
investigated to be integrated into a single, high-throughput portable device.
These approached were implemented in detection of biological compounds
(proteins and antibodies) via RNA functionalization coatings, and in detection
of pesticides and explosive molecules throughout chemical surface treatments.