MULTI-ENZYME SYSTEMS IN SOLID-PHASE; THE NEW WAVE OF THE SYNTHETIC BIOLOGY
CIC nanoGUNE Seminars
- Speaker
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Fernando López Gallego, CIC biomaGUNE, Donostia, Spain
- When
-
2014/07/28
13:00 - Place
- nanoGUNE seminar room, Tolosa Hiribidea 76, Donostia - San Sebastian
- Add to calendar
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**Host: R. Perez-Jimenez**
CORRECTION: 28TH JULY MONDAY
N **anobiotechnology and synthetic biology** are emerging disciplines that
merge biology and chemistry to assemble biological machineries onto
functionalized nano/micro-structured materials. Nowadays, developing of novel
advanced materials is broadening the application of this discipline; however
the incorporation of complex biological machineries to such materials is still
an unmet need. Integration of advanced biological machineries (i.e.
transcription/translation, photosynthetic or CO2 fixation systems) into nano-
surfaces (i.e nanoparticles, nanotubes or nanowires) devises more complex
functionalities of nanomaterials that will provide new solution for chemistry,
medicine or applied life sciences. Inspired by the exquisite **orchestration
of biological machineries** found in nature, researchers exploit them in
artificial applications. This has become a reality by a multidisplinar
approach that combines different areas such as protein engineering, surface
chemistry and material science. Our research group has so far been focused
mostly on applying multi-step biocatalytic strategies to synthetic and
analytical chemistry by harnessing the exquisite selectivity of enzymes
(biological catalysts) for the development of more sustainable and effective
chemical processes. We pursue mimicking the spatial organization found inside
the living organisms, but using _ex-vivo_ systems supported on solid
materials. To address such goal, we are interfacing chemistry and biology a)
to assemble multi-enzyme cascades on porous carriers by activating such
surfaces with different chemical groups that selectively immobilize the
different enzymes (i.e. cofactor recycling systems integrated to redox
enzymes) **(1,2)** b) to create synthetic scaffolds inspired in biological
organizations to assemble biocatalytic cascades inside porous material with
fine control of the nanometric localization of each biocatalyst and c) to
create novel semi-synthetic proteins with artificial functionalities **(3)**.