DIPC Community Seminar: Flavin photocatalysis for the activation and delivery of metallodrugs

DIPC Seminars

Speaker

Luca Salassa
DIPC

When

2024/09/26
12:00

Place

DIPC Seminar Room

Host

Carlos Sanchez Cano

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DIPC Community Seminar

In recent years, our research has demonstrated the efficacy of flavins and flavoproteins as selective and efficient photocatalysts in activating metal-based anticancer drugs [1-3]. Specifically, we have illustrated that flavin catalysts can photoconvert Pt(IV) precursors into clinically approved Pt(II) agents in the presence of bioreductants, thereby inducing antiproliferative effects in cancer cells with minimal light exposure [1]. Unconventionally, metal complexes act as substrates in these reactions, rather than catalysts as commonly observed in catalysis. In this contribution, I will emphasize how we have leveraged this chemistry to develop novel strategies for activating and
delivering anticancer metallodrugs [4,5].

[1] S. Alonso-de Castro, E. Ruggiero, A. Ruiz-de-Angulo, E. Rezabal, J. C. Mareque-Rivas, X. Lopez, F. López-Gallego, L. Salassa, Chem. Sci., 8, 4619 (2017).[2] S. Alonso-de Castro, A. L. Cortajarena, F. López- Gallego, L. Salassa, Angew. Chem. Int. Ed., 57, 3143 (2018).
[3] J. Gurruchaga-Pereda, V. Martínez-Martínez, E. Rezabal, X. Lopez, C. Garino, F. Mancin, A. L. Cortajarena, L. Salassa, ACS Catal., 10, 187 (2020).[4] S. Velasco-Lozano, S. Alonso-de Castro, C. Sanchez-Cano, A. I. Benítez-Mateos, F. López-Gallego, L. Salassa, Chem Sci, 13, 59 (2022).
[5] L. F. Mazzei, J. Gurruchaga-Pereda, Á. Martínez, J.Calvo Martínez, L. Salassa, A. L. Cortajarena, Chem. Commun., 59, 4754 (2023).

Zoom: https://dipc-org.zoom.us/j/97048979421

Youtube: https://youtube.com/live/hRjr8mhhpH8