Membrane mechanics and dynamics: From in-vitro to in-vivo
DIPC Seminars
- Speaker
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Adai Colom Diego, Biofisika Institute, UPV/EHU, Bilbao
- When
-
2021/05/14
14:00 - Place
- Online Seminar, Donostia International Physics Center
- Add to calendar
- iCal
Organelles and cells are delimited by a lipid bilayer, which is highly
deformable, a property essential to many cell processes such as motility,
endocytosis, cell division. During these deformations, lipid membranes
experience stretch causing membrane tension. Membrane tension and membrane
proteins are main regulators of the cell processes that remodel membranes,
albeit, it is difficult to measure in vivo. FliptR (for Fluorescent LIPid
Tension Reporter) can monitor changes of membrane tension by changing its
fluorescence lifetime as a function of the twist between its fluorescent
groups, allowing for an easy quantification of membrane tension by
fluorescence lifetime imaging microscopy (FLIM). From other hand, HS-AFM has
been proven a unique and powerful tool for the analysis of the structure and
dynamics of single biomolecules which change the membrane properties as ESCRT
III, Dynamin or antibiotic treatments.
Host: David de Sancho
ZOOM: https://dipc-org.zoom.us/j/85943558847
YouTube: https://youtu.be/iyx0wC6Gf3E