Triggering molecular transport via pulse magnetic fields
DIPC Seminars
- Speaker
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Viktor Chikan, Department of Chemistry, Kansas State University
- When
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2022/05/13
12:00 - Place
- Hybrid Seminar, Donostia International Physics Center
- Add to calendar
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iCal
**Topic 1:** Ultrasound generated from magnetic nanoparticles for drug
delivery and cancer therapy: The widespread use of nanoparticles in technology
is still limited by the available tools at nanoscale to control their
properties. Our group at Kansas State University exploring how to amplify
magnetic fields effects on liposomal drug delivery systems and on cells for
cancer therapy. We have been studying the effect of inhomogeneous magnetic
pulses on strong inhomogeneous magnetic fields, which can produce localized
ultrasound to alter permeability of lipid bilayers (JPCB 2014, 118 (40),
11715-22). Magnetoliposomes (liposomes loaded with magnetic nanoparticles)
combined with the intense inhomogeneous magnetic pulses can be used to develop
rapid drug release methodology to address some of the shortcomings of
currently available liposomes delivery systems (Magnetochemistry 2020, 6(4),
52). In addition, we have shown (ACS Applied Materials & Interfaces 2020, 12
(12), 13657-13670.) that the commercially available glucose-coated magnetic
nanoparticles accumulated in U937 cell lines prior to application of magnetic
pulses and shown no adverse effects on cell viability. Our investigations
explored the possibility of increase cell death while concurrently increasing
accumulation of doxorubicin via application of inhomogeneous magnetic fields
assisted by magnetic particles.
**Topic 2:** User end station development at ELI-ALPS research
facility/Hungary
The Extreme Light Infrastructure Attosecond Light Pulse Source (ELI-ALPS)
located in Europe is a large-scale ultrafast user facility. Our team, the
Ultrafast Dynamics group at ELI-ALPS serves international users’ needs in
ultrafast pump probe experiments. Our research focuses on ultrafast dynamical
processes in the gas phase and in the condense phase. E.g. The group aims at
investigating experimentally the impact of the intense and slow ‘quasi
static’ terahertz (THz) electric fields on chemical reactions and exciton
dynamics. The THz will play a role in aligning molecules (Phys. Rev. Lett.,
2011 107, 163603) and manipulating polarizable electronic states (JPCA, 2012,
116, 11228) for controlling outcome in simple chemical reactions such as in
photodissociation reactions. For detection, we apply novel chemiluminescence
based time resolved Fourier Transform Visible Spectroscopy (FTVIS), which is a
relatively new methodology explore energy disposal from photodissociation of
small molecules (JPCA 2020, 124, 14, 2755–2767). Photodissociation is
initiated by intense IR femtosecond pulses/attosecond/XUV pulses and allows to
obtain detailed chemical information such as the presence of neutral fragments
in Coulomb explosion experiments. In parallel to the gas phase experiments,
our transient absorption spectroscopic apparatus investigates ultrafast
dynamics in the condense phase. Our current research aims at addressing
questions how transient absorption spectroscopic methodology can provide in
situ ultrafast experimental data at elevated temperatures on colloidal
nanoparticle systems. We are currently investigating the acoustic vibrational
modes of gold nanoparticles/nanorods during high temperature growth and the
ionization of doped semiconductor quantum dots (Ga,In,Sn CdSe/ZnS) with the
help of in situ transient absorption technique.
Host: Geza Toth
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