CANCELLED - Chitosan based systems for biomedical and pharmaceutical applications
DIPC Seminars
- Speaker
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Carlos Andrés Peniche Covas, Facultad de Química, Universidad de La Habana, Cuba
- When
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2022/05/19
14:00 - Place
- Hybrid Seminar, Donostia International Physics Center
- Add to calendar
-
iCal
Chitosan is a linear polysaccharide composed of two structural units
distributed along the macromolecular chain in a random manner, N-aceyl-D-
glucosamine and Dglucosamine bound together by b(1-4) glycoside links.
Commercial chitosan is generally obtained by the extensive deacetylation of
chitin (namely, poly(N-acetyl-Dglucosamine), natural polysaccharide extracted
from crustacean shells.
Chitosan is soluble in dilute aqueous solutions of many organic and inorganic
acids, producing highly viscous solutions. It forms chelates with transition
and posttransition metal ions, is amenable to chemical modification due to its
–OH and -NH2 groups, and can be processed into gels, films, fibers,
microspheres and nanoparticles.
Chitosan is biocompatible, biodegradable and non-toxic. It is mucoadhesive,
haemostatic, hipocolesterolemic, hipolipidemic, and possesses antiviral and
antimicrobial activity. These remarkable biological properties, together with
the above mentioned physical and chemical properties make it an attractive
polymer for applications in medicine and pharmacy.
The aim of this talk is to present some results obtained on the preparation of
different chitosan based systems with potential application in drug delivery
and tissue engineering, such as: pH sensitive hydrogels obtained from the
polymerization of acrylic monomers in the presence of chitosan, microparticles
generated by simple coacervation, nanoparticles prepared by complex
coacervation,
nanoparticles obtained by self-assembling of soluble chitosan derivatives
grafted with lipophilic drugs, and chitosan/apatite composites for bone
repair.
Host: Fabienne Barroso
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