Magnetic Response of Functionalized Lipid Bilayers

DIPC Seminars

Joachim Kohlbrecher (Paul Scherrer Institut, Villigen, Switzerland)
Donostia International Physics Center (DIPC). Paseo Manuel de Lardizabal, 4, Donostia
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Magnetic Response of Functionalized Lipid Bilayers Dr. Joachim Kohlbrecher Paul Scherrer Institut Villigen, Switzerland **Magnetic Response of Functionalized Lipid Bilayers** Magnetic field effects on biological molecules are rarely observed, due to the small diamagnetic susceptibility of individual molecules. In self-assembly systems, such as phospholipid bilayers, where the molecules are aggregated parallel to each other, the anisotropy of the diamagnetic susceptibility become additive and a magnetic orientation in a magnetic field becomes possible. A well-known system, where this magnetic orientation has been exploited, is a bicellar mixture of long and short chain phospholipids used in NMR studies of transmembrane proteins. By doping these aggregates with paramagnetic lanthanides conferring a large magnetic moment, the responsiveness to magnetic fields can be enhanced. The effect of magnetic fields on phospholipid vesicles and bicelles containing a chelator-lipid with complexed paramagnetic lanthanides will be shown. Another route to add magnetic response to lipid bilayers is to incorporate ferromagnetic nanoparticles into them. We succeeded to implement iron oxide nanoparticles into the membrane of a lipid vesicle to control the release through magnetic actuation. [1] ACS Applied Materials & Interfaces, 2014, 6, 1100-1105 [2] Patent WO2014128002 (A1) [3] The Journal of Physical Chemistry B, 2013, 117, 14743-14748 [4] Langmuir, 2013, 29, 3467-3473 [5] Langmuir, 2012, 28, 10905-10915 [6] Langmuir, 2010, 26, 5382-5387 [7] Nano Letters, 2011, 11, 1664-1670 [8] J. Phys. Chem. B, 2010, 114, 174-186